MB Comment: In other words: the pertussis vaccine is ineffective and vaccinated people can spread pertussis. Do health officials care? Of course not – they recommend vaccinating everyone with this ineffective vaccine and blame the unvaccinated for spreading pertussis. Are health officials following a legitimate scientific method when they tout this vaccine and demonize the unvaccinated? No, vaccines are their religion and they are a crazy cult. Bactericidal definition: preventing infection by inhibiting the growth or action of microorganisms.
Characterization of Bactericidal Immune Responses following Vaccination with Acellular Pertussis Vaccines in Adults
American Society for Microbiology December 2000
+ Author Affiliations
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio1;
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas2; and
Department of Pediatrics, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee3
Sera from six adults, collected before and after acellular pertussis vaccination, and from a placebo control were examined for the ability to elicit two bactericidal immune defenses, (i) antibody-dependent complement-mediated bacterial lysis and (ii) opsonization and phagocytosis by human neutrophils. The samples were chosen based on low preimmunization titers and strong postimmunization responses to various combinations of vaccine antigens. All but two prevaccination samples demonstrated activity indicative of complement-mediated lysis. Preimmunization activity could have been due to prior infection or childhood immunization. Immunization did not result in improved bactericidal activity for any of the individuals, and in two cases immunization caused a statistically significant decrease in complement-mediated lysis. Similarly, opsonization with the postimmunization sera failed to enhance attachment or phagocytosis of bacteria by neutrophils, and one postimmunization sample with a strong response to filamentous hemagglutinin caused an inhibition of phagocytosis that was statistically significant compared to that observed for the no-serum control. In summary, booster immunization of adults with acellular pertussis vaccines was not found to increase bactericidal activity over preimmunization levels. Identifying ways to promote bactericidal immune responses might improve the efficacy of acellular pertussis vaccines.